Piperacillin/tazobactam versus cefotaxime plus metronidazole for treatment of children with intra-abdominal infections requiring surgery

• Published in: European journal of clinical microbiology & infectious diseases Vol. 20; no. 9; pp. 643 - 646
• Main Authors: MALTEZOU, H. C, NIKOLAIDIS, P, LEBESII, E, DIMITRIOU, L, ANDROULAKAKIS, E, KAFETZIS, D. A
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.09.2001; Springer Nature B.V
• Subjects: Abdominal Abscess - drug therapy; Abdominal Abscess - microbiology; Abdominal Abscess - surgery; Adolescent; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Appendicitis - drug therapy; Appendicitis - microbiology; Appendicitis - surgery; Bacterial Infections - drug therapy; Bacterial Infections - microbiology; Biological and medical sciences; Cefotaxime - administration & dosage; Child; Child, Preschool; Drug Combinations; Drug Therapy, Combination - administration & dosage; Female; Follow-Up Studies; Humans; Intestinal Perforation - drug therapy; Intestinal Perforation - microbiology; Intestinal Perforation - surgery; Male; Medical sciences; Metronidazole - administration & dosage; Microbial Sensitivity Tests; Penicillanic Acid - administration & dosage; Penicillanic Acid - analogs & derivatives; Peritonitis - drug therapy; Peritonitis - microbiology; Peritonitis - surgery; Pharmacology. Drug treatments; Piperacillin - administration & dosage; Prospective Studies; Tazobactam; Treatment Outcome; Intravenous administration; Cefotaxime; β-Lactamase; Penicillin derivatives; Antifungal agent; Piperacillin; Intestinal disease; Child; Peritonitis; Human; Drug combination; Enzyme; Appendicitis; Treatment efficiency; β-Lactams; Abscess; Abdomen; Infection; Antibiotic; Chemotherapy; Treatment; Tazobactam; Abdominal disease; Bacteriosis; Digestive diseases; Hydrolases; Metronidazole; Antibacterial agent; Therapeutic protocol; Comparative study
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/s100960100581

The efficacy of piperacillin/tazobactam at 100/12.5 mg/kg every 8 h (35 patients) was compared to cefotaxime plus metronidazole at 50/7.5 mg/kg every 8 h (35 patients) in 70 children with intra-abdominal infections requiring surgery. Diagnoses were gangrenous or perforated appendicitis (n =56), peritonitis (n =12), and abscess (n =2). Clinical cure was observed in 35 of 35 evaluable patients treated with piperacilin/tazobactam and in 34 of 34 evaluable patients treated with cefotaxime plus metronidazole. Presumed bacteriological eradication was noted in 29 of 30 evaluable patients in the piperacillin/tazobactam group and in 31 of 31 evaluable patients in the cefotaxime plus metronidazole group. In this study, piperacillin/tazobactam was as effective as cefotaxime plus metronidazole for treating children with intra-abdominal infections requiring surgery.