Establishment of Monoclonal Antibody PMab-202 Against Horse Podoplanin

• Published in: Monoclonal antibodies in immunodiagnosis and immunotherapy Vol. 37; no. 5; p. 233
• Main Authors: Furusawa, Yoshikazu, Yamada, Shinji, Itai, Shunsuke, Sano, Masato, Nakamura, Takuro, Yanaka, Miyuki, Handa, Saori, Mizuno, Takuya, Maeda, Ken, Fukui, Masato, Harada, Hiroyuki, Kaneko, Mika K, Kato, Yukinari
• Format: Journal Article
• Language: English
• Published: United States 01.11.2018
• Subjects: Animals; Antibodies, Monoclonal - biosynthesis; Antibodies, Monoclonal - genetics; Antibodies, Monoclonal - immunology; Antibody Specificity - immunology; CHO Cells; Cricetinae; Cricetulus; Epitope Mapping; Epitopes - immunology; Flow Cytometry; Horses - immunology; Humans; Lectins, C-Type - immunology; Membrane Glycoproteins - genetics; Membrane Glycoproteins - immunology; Mice; Platelet Aggregation - immunology; Podocytes - immunology; horse podoplanin; PDPN; PMab-202

Podoplanin (PDPN), a type I transmembrane glycoprotein, is expressed in several body tissues, including podocytes of renal glomerulus, type I alveolar cells of lung, and lymphatic endothelial cells. PDPN activates platelet aggregation by binding to C-type lectin-like receptor-2 (CLEC-2) presented on...