Evaluation of T-Type Calcium Channel Blockers against Human Pancreatic MIA PaCa-2 Carcinoma Xenografts

Two piperazine-containing 3,4-dihyroquinazolines (BK10007S/8S) have been synthesized, based on our previous work on the synthesis and antitumoral activity of 3,4-dihyroquinazolines. After evaluating them for T-type calcium channel blocking effect and in vitro anti-cancer effect, they were profiled f...

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Published inBulletin of the Korean Chemical Society Vol. 34; no. 2; pp. 482 - 488
Main Authors Park, Jin Yeong, Choi, Heung Woo, Choi, Doo Li, Jang, Sun Jeong, Kim, Je Hak, Lee, Joo Han, Choo, Dong Joon, Kim, Jungahn, Lee, Kyung-Tae, Lee, Jae Yeol
Format Journal Article
LanguageEnglish
Published 대한화학회 20.02.2013
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화학
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Summary:Two piperazine-containing 3,4-dihyroquinazolines (BK10007S/8S) have been synthesized, based on our previous work on the synthesis and antitumoral activity of 3,4-dihyroquinazolines. After evaluating them for T-type calcium channel blocking effect and in vitro anti-cancer effect, they were profiled for acute and repeat dose toxicity (40 mg/kg, 2 weeks) to BALB/c mice. BK10007S/8S were further in vivo evaluated against human pancreatic MIA PaCa-2 carcinoma in BALB/cnu/nu nude mice, which exhibited 54 and 61% tumor growth inhibition through 57-day oral administration of 2 mg/kg of body weight, respectively. KCI Citation Count: 6
Bibliography:http://journal.kcsnet.or.kr/main/j_search/j_abstract_view.htm?code=B130229&qpage=j_search&spage=b_bkcs&dpage=ar
G704-000067.2013.34.2.038
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2013.34.2.482