Pericytes in Skeletal Muscle

Skeletal muscle regeneration is a highly orchestrated process and involves the activation of many cellular and molecular pathways. Although satellite cells (SCs) are the major cell type responsible for muscle regeneration, pericytes show remarkable myogenic potential and various advantages as cell t...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 1122; p. 59
Main Authors Gautam, Jyoti, Yao, Yao
Format Journal Article
LanguageEnglish
Published United States 01.01.2019
Subjects
Cell Differentiation
Humans
Muscle Development
Muscle, Skeletal - cytology
Muscular Dystrophies
Myoblasts - cytology
Pericytes - cytology
Regeneration
Muscle injury
Satellite cells
Mesoangioblasts
Muscular dystrophy
Myogenesis
Ossification
Fibrosis
Pericytes
Chondrogenesis
Differentiation
Muscle regeneration
Osteogenesis
Adipogenesis
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Summary:Skeletal muscle regeneration is a highly orchestrated process and involves the activation of many cellular and molecular pathways. Although satellite cells (SCs) are the major cell type responsible for muscle regeneration, pericytes show remarkable myogenic potential and various advantages as cell therapy in muscular disorders. This chapter first introduces the structure, marker expression, origin, and category of pericytes. Next, we discuss their functions in muscular dystrophy and/or muscle injuries, focusing on their myogenic, adipogenic, fibrogenic, chondrogenic, and osteogenic activities. Understanding this knowledge will promote the development of innovative cell therapies for muscle disorders, including muscular dystrophy.
ISSN:0065-2598
DOI:10.1007/978-3-030-11093-2_4