The effect of a single dose of arecholine and atropine administration on activities of carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase in the nervous system of rats

The effect of a single dose of arecholine and atropine administration on the activities of carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase involved into the final stage of formation of biologically active neuropeptides from precursors has been studied in brain and adr...

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Published inBiochemistry (Moscow). Supplement. Series B, Biomedical chemistry Vol. 2; no. 2; pp. 183 - 188
Main Authors Solov’ev, V. B., Gengin, M. T.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.06.2008
Springer Nature B.V
Subjects
Bioorganic Chemistry
Brain
Chemistry
Chemistry and Materials Science
Enzymes
Experimental Studies
Medicinal Chemistry
Nervous system
Peptides
Pharmacology
Rodents
arecholine
neuropeptides
phenylmethylsulfonyl fluoride-inhibited carboxypeptidase
brain
carboxypeptidase H
atropine
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Summary:The effect of a single dose of arecholine and atropine administration on the activities of carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase involved into the final stage of formation of biologically active neuropeptides from precursors has been studied in brain and adrenals. Changes in the enzyme activities were evident during at least 72 h after administration of these drugs to rats. These results suggest that the decrease in the activity of these enzymes may represent one of possible mechanisms involved into reduction of neuropeptide levels during inhibition and activation of cholinergic system.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750808020091