New Short Synthesis of (5)-2,3-Dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodobenzamide: Dopamine D2 Receptor

A new short and highly efficient synthesis of (5)-2,3-dimethoxy-N[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodobenzamide (epidepride, 1) from 3-methoxy-salicylaldehyde (o-vanillin, 2) and 3-methoxysalicyclic acid (6) was achieved by employing a new iodination method with iodine monochloride and iodine nitr...

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Bibliographic Details
Published inSynthetic communications Vol. 38; no. 3; pp. 434 - 440
Main Authors Joshua, Alummoottil V., Sharma, Sanjay K., Abrams, Douglas N.
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 01.01.2008
Taylor & Francis
Subjects
Chemistry
Chemistry, Organic
dopamine D2 receptor
epidepride
iodine monochloride
iodine nitrate
Physical Sciences
Science & Technology
ACID
epidepride
iodine nitrate
IODONIUM NITRATE
RADIOLIGAND
PYRIDINE
POLYHALIDES
IODINE
HALOGENS
I-125 EPIDEPRIDE
dopamine D2 receptor
CHEMISTRY
iodine monochloride
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Summary:A new short and highly efficient synthesis of (5)-2,3-dimethoxy-N[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodobenzamide (epidepride, 1) from 3-methoxy-salicylaldehyde (o-vanillin, 2) and 3-methoxysalicyclic acid (6) was achieved by employing a new iodination method with iodine monochloride and iodine nitrate under basic conditions.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910701771199