Performance of a Risk Index for Advanced Proximal Colorectal Neoplasia Among a Racially/Ethnically Diverse Patient Population (Risk Index for Advanced Proximal Neoplasia)

• Published in: The American journal of gastroenterology Vol. 106; no. 6; pp. 1099 - 1106
• Main Authors: Levitzky, Benjamin E, Brown, Colin C, Heeren, Timothy C, Schroy, Paul C
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.06.2011; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: African Americans - statistics & numerical data; Age Distribution; Aged; Area Under Curve; Biological and medical sciences; Colonoscopy - methods; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - ethnology; Colorectal Neoplasms - pathology; Cross-Sectional Studies; Early Detection of Cancer - methods; Ethnic Groups - statistics & numerical data; European Continental Ancestry Group - statistics & numerical data; Female; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Hispanic Americans - statistics & numerical data; Humans; Incidence; Logistic Models; Male; Medical sciences; Middle Aged; Neoplasm Staging; Odds Ratio; Reproducibility of Results; Retrospective Studies; Risk Assessment; Sex Distribution; Sigmoidoscopy - methods; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; United States - epidemiology; United States; Colonic disease; Performance evaluation; Human; Proximal; Rectal disease; Colorectal cancer; Risk factor; Gastroenterology; Digestive diseases; Intestinal disease; Malignant tumor; Cancer
• ISSN: 0002-9270; 1572-0241; 1572-0241
• DOI: 10.1038/ajg.2011.20

Tailoring the use of screening colonoscopy based on the risk of advanced proximal neoplasia (APN) has been advocated as a strategy for reducing demand and optimizing effectiveness. A 7-point index based on age, sex, and distal findings at sigmoidoscopy has been proposed that stratifies individuals into low, intermediate, and high-risk categories. The aim of this cross-sectional analysis was to determine the validity of this index, which was originally derived and validated among mostly whites, for black and Hispanic patients. Data, including age, sex, colonoscopic findings, and pathology, were collected retrospectively from 1,481 white, 1,329 black, and 689 Hispanic asymptomatic, average-risk patients undergoing screening colonoscopy between 2000 and 2005. Cumulative scores ranging from 0 to 7 were derived for each subject and categorized as low, intermediate, or high risk. Rates of APN were assessed for each risk category after stratification by race/ethnicity. Index performance was assessed using the C-statistic and compared across the three racial groups. Rates of APN among patients categorized as low, intermediate, or high risk increased from 1.0 to 2.8 to 3.7% for whites, 1.0 to 2.2 to 4.2% for blacks, and 0.6 to 1.9 to 3.7% for Hispanics. The index performed similarly for all three groups, but showed limited ability to discriminate low from intermediate-risk patients, with C-statistic values of 0.62 for whites, 0.63 for blacks, and 0.68 for Hispanics. A risk index based on age, sex, and distal endoscopic findings has limited ability to discriminate low from intermediate-risk white, black, and Hispanic patients for APN.