Systemically administered mini α-crystallin peptide delays cataract progression in streptozotocin-induced diabetic rats

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 7; p. 130814
• Main Authors: Savitikadi, Pandarinath, Dash, Lucky, Angadi, Kiran Kumar, Reddy, G. Bhanuprakash, Reddy, V. Sudhakar
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2025
• Subjects: alpha-Crystallin A Chain; alpha-Crystallin B Chain - administration & dosage; alpha-Crystallins - administration & dosage; Animals; apoptosis; Apoptosis - drug effects; caspase-3; Cataract; Cataract - drug therapy; Cataract - etiology; Cataract - metabolism; Cataract - pathology; Cataract - prevention & control; Diabetes; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; Disease Progression; endoplasmic reticulum; Endoplasmic Reticulum Stress - drug effects; eye lens; hyperglycemia; Lens, Crystalline - drug effects; Lens, Crystalline - metabolism; Lens, Crystalline - pathology; Male; mammals; Mini peptide; oxidative stress; Oxidative Stress - drug effects; peptides; Peptides - administration & dosage; Peptides - pharmacology; Protein aggregation; protein content; Rats; Rats, Sprague-Dawley; Streptozocin; Streptozotocin; therapeutics; Α-Crystallin; Cataract; Protein aggregation; Diabetes; Α-Crystallin; Streptozotocin; Mini peptide

α-Crystallin in the mammalian eye lens composed of αA-Crystallin (αAC) and αB-Crystallin (αBC) subunits present in a 3:1 ratio. These proteins exhibit chaperone-like activity, helping to protect cells from various forms of stress. Specific sequences within αAC (70KFVIFLDVKHFSPEDLTVK88) and αBC (73DR...