Synthesis, characterization, and DNA-binding properties of copper(II), cobalt(II), and nickel(II) complexes with salicylaldehyde 2-phenylquinoline-4-carboylhydrazone

Salicylaldehyde 2-phenylquinoline-4-carboylhydrazone (H 2 L), and its novel copper(II), cobalt(II), and nickel(II) complexes MHL · Cl ·  n H 2 O [M=Cu n  = 3 ( 1 ), M=Co n  = 2 ( 2 ), M=Ni n  = 3.5 ( 3 )] have been synthesized and characterized by elemental analysis, molar conductivity, spectroscopi...

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Published inTransition metal chemistry (Weinheim) Vol. 33; no. 2; pp. 267 - 273
Main Authors Xu, Zhi-hong, Xi, Pin-xian, Chen, Feng-juan, Liu, Xiao-hui, Zeng, Zheng-zhi
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.03.2008
Springer Nature B.V
Subjects
Catalysis
Chemistry
Chemistry and Materials Science
Deoxyribonucleic acid
DNA
Inorganic Chemistry
Organometallic Chemistry
Physical Chemistry
Spectrum analysis
Quinoline
Aminomethane Hydrochloride
Intrinsic Binding Constant
Hydrazide
Salicylaldehyde
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Summary:Salicylaldehyde 2-phenylquinoline-4-carboylhydrazone (H 2 L), and its novel copper(II), cobalt(II), and nickel(II) complexes MHL · Cl ·  n H 2 O [M=Cu n  = 3 ( 1 ), M=Co n  = 2 ( 2 ), M=Ni n  = 3.5 ( 3 )] have been synthesized and characterized by elemental analysis, molar conductivity, spectroscopic, and thermal analysis. The interaction of these complexes with calf thymus DNA was investigated by UV absorption spectroscopy, fluorescence spectroscopy, cyclic voltammetry, and viscosity measurements. The results suggest that these complexes bind to DNA via an intercalation binding mode and their affinity to DNA follows the order of 3  >  1 >  2 .
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ISSN:0340-4285
1572-901X
DOI:10.1007/s11243-007-9038-7