Efficient and Practical Synthesis of Mannich Bases Related to Gramine Mediated by Zinc Chloride

An efficient and practical procedure for the Mannich reaction of secondary amine, formaldehyde, and indole or N-methylindole employing zinc chloride is presented. A series of gramine derivatives were obtained in 58-98% yields at room temperature in EtOH by using this method.

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Bibliographic Details
Published inSynthetic communications Vol. 36; no. 13; pp. 1829 - 1835
Main Authors Dai, Hong-Guang, Li, Ji-Tai, Li, Tong-Shuang
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 01.07.2006
Taylor & Francis
Subjects
Chemistry
Chemistry, Organic
Gramine
Mannich reaction
Physical Sciences
Science & Technology
synthesis
zinc chloride
synthesis
ACID
zinc chloride
gramine
Mannich reaction
INDOLES
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Summary:An efficient and practical procedure for the Mannich reaction of secondary amine, formaldehyde, and indole or N-methylindole employing zinc chloride is presented. A series of gramine derivatives were obtained in 58-98% yields at room temperature in EtOH by using this method.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910600602503