Association of Rs7217186 Polymorphism of Arachidonic Acid 15-Lipoxygenase (ALOX15) Gene with Susceptibility to Allergic Rhinitis

• Published in: Reports of biochemistry and molecular biology Vol. 12; no. 2; pp. 269 - 276
• Main Authors: Eivazi, Atefeh, Akbari, Bahman, Falahi, Sara, Gorgin Karaji, Ali, Rezaiemanesh, Alireza, Mortazavi, Seyed Hamid Reza, Daneshfar, Niloofar, Salari, Farhad
• Format: Journal Article
• Language: English
• Published: Iran Varastegan Institute for Medical Sciences 01.07.2023
• Subjects: Original; Specialized proresolving lipid mediators (SPMs); Immunoresolvents; Single-nucleotide polymorphism; Allergic rhinitis; Arachidonate 15-lipoxygenase
• ISSN: 2322-3480; 2322-3480
• DOI: 10.61186/rbmb.12.2.269

Allergic rhinitis (AR) is an inflammatory disorder of the nasal mucosa, caused by exposure to environmental allergens. It is known that 15-lipoxygenase (15-LOX) is involved in the biosynthetic pathways of anti-inflammatory lipid mediators, including resolvins and protectins. In this study, which was performed on 130 AR patients and 130 healthy controls, we aimed to investigate the association of susceptibility to AR with two selected single-nucleotide polymorphisms (SNPs), that is, rs2619112:A>G and rs7217186:C>T, in the intron regions of arachidonic acid 15-LOX ( ) gene, using SNPinfo and Regulome DB tools. The results showed that the CT genotype of rs7217186: C>T was significantly associated with the increased risk of AR compared to the CC genotype (P= 0.037, OR=1.943, CI: 1.038-0.638). However, there was no strong evidence of the association of rs2619112: A>G with susceptibility to AR (P> 0.05). The present results indicated that rs7217186 polymorphism of ALOX15 gene might be a potential biomarker for susceptibility to AR.