Association between perfluoroalkyl substances and breast cancer on the National Health and Nutrition Examination Survey Database and meta-analysis

• Published in: Journal of hazardous materials Vol. 477; p. 135219
• Main Authors: Jia, Conghui, Li, Yanchao, Cao, Yuxuan, Zhou, Zilin, Liu, Yuan, Guo, Yang, Liu, Wenxuan, Yang, Lei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.09.2024
• Subjects: Adult; Breast cancer; breast neoplasms; Breast Neoplasms - chemically induced; Breast Neoplasms - epidemiology; confidence interval; Databases, Factual; Environmental Pollutants; Female; Fluorocarbons - analysis; Humans; Meta-analysis; National Health and Nutrition Examination Survey; NHANES; Nutrition Surveys; odds ratio; perfluorocarbons; PFASs; regression analysis; risk; United States - epidemiology; United States; RR; CDC; PFASs; HR; PFNA; LC–MS/MS; PFDE; PFDA; PFCAs; UPLC-ESI-MS/MS; WHO; OR; PFHS; PFHxS; PFSAs; PFUA; Breast cancer; IARC; PFOA; MPAH; LC-ESI-MS/MS; Meta-analysis; GC-MS; HPLC-MS/MS; NOS; UPLC-MS/MS; NHANES; GC-NCI-MS; PFOS
• ISSN: 0304-3894; 1873-3336; 1873-3336
• DOI: 10.1016/j.jhazmat.2024.135219

The relationship between perfluoroalkyl substances (PFASs) and the risk of breast cancer has been controversial. Here, we used the National Health and Nutrition Examination Survey (NHANES) database and a meta-analysis to examine the association between PFASs and breast cancer incidence. From the NHANES database, we obtained data on PFASs and breast cancer from 2003 to 2014. We searched PubMed, Web of Science, Scopus and PsycINFO from the establishment of the databases to August 24, 2023, for research on PFASs related to breast cancer. A meta-analysis was performed using Stata 12.0. A total of 1430 subjects aged 20 years or older were selected from the NHANES. The logistic regression results indicated that there was no correlation between breast cancer and PFASs (P > 0.05). The meta-analysis, included nine studies with a total of 2399 breast cancer patients, included in the meta-analysis, revealed no statistically significant association between PFASs and the risk of breast cancer (odds ratio = 1.04; 95 % confidence interval, 0.88–1.21; P > 0.05). The results show that PFASs are not associated with breast cancer risk. [Display omitted] •First meta-analysis of PFAS and breast cancer combined with NHANES database.•PFHxS, PFDA were inversely related to different hormone receptor of breast cancer.•There was a dose-response relationship between PFAS and breast cancer.