A new platelet parameter, the mean platelet component, can demonstrate abnormal platelet function and structure in myelodysplasia

• Published in: Clinical and laboratory haematology Vol. 25; no. 1; pp. 59 - 62
• Main Authors: Brummitt, D.R., Barker, H.F., Pujol‐Moix, N.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.02.2003; Blackwell Science
• Subjects: ADVIATM 120; Biological and medical sciences; Blood Platelet Disorders - diagnosis; Blood Platelet Disorders - pathology; Blood Platelets - pathology; Blood Platelets - ultrastructure; Female; Hematologic and hematopoietic diseases; Hemorrhage - etiology; Hemorrhage - pathology; Humans; Mean platelet component; Medical sciences; Microscopy, Electron; Middle Aged; myelodysplasia; Myelodysplastic Syndromes - blood; Myelodysplastic Syndromes - complications; Platelet diseases and coagulopathies; platelet function; Platelet Function Tests - instrumentation; Platelet Function Tests - methods; platelet transmission electron microscopy; Human; platelet transmission electron microscopy; ADVIA# 120; Exploration; Malignant hemopathy; Myelodysplastic syndrome; Case study; Platelet; Transmission electron microscopy; myelodysplasia; Ultrastructure; Platelet function; Diagnosis; Mean platelet component
• ISSN: 0141-9854; 1365-2257
• DOI: 10.1046/j.1365-2257.2003.00488.x

Summary The mean platelet component (MPC) is a new platelet parameter generated by the Bayer ADVIATM 120 full blood count analyser as part of the routine complete blood count (CBC) test cycle. We report a case of myelodysplasia with bleeding complications and abnormal template bleeding time in whom low mean platelet component parameters were associated with partial platelet granule deficiency, demonstrated by transmission electron microscopy. We suggest that the mean platelet component is an inexpensive and rapid test to screen for platelet dysfunction related to ultrastructural abnormalities in myelodysplasia.