Insulin‐like growth factors I and II
This chapter will serve as a mini-review of the field of IGF, presenting the most prominent biochemical and clinical aspects of IGF, in which only review articles will be cited. IGF I and II are single-chain polypeptides of about 7.5 kDa which occur in blood plasma at concentrations of 20-80 nM and...
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Published in | European journal of biochemistry Vol. 190; no. 3; pp. 445 - 462 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
05.07.1990
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | This chapter will serve as a mini-review of the field of IGF, presenting the most prominent biochemical and clinical aspects of IGF, in which only review articles will be cited. IGF I and II are single-chain polypeptides of about 7.5 kDa which occur in blood plasma at concentrations of 20-80 nM and at lower concentrations in most if not all tissues of the body. IGF circulating in the blood is probably produced by the liver, whereas tissue IGF is produced to a greater part locally. The significance of endocrine vs paracrine/autocrine actions is at present not clear. The expression of IGF I and, to a lesser degree, of IGF II is under the control of GH. IGF I acts as feedback inhibitor at the pituitary level of the GH release and/or GH gene transcription. IGF I can mimic most, but probably not all, effects of GH. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0014-2956 1432-1033 |
DOI: | 10.1111/j.1432-1033.1990.tb15595.x |