LAÇASSE CATALYZED-SYNTHESIS OF 4,4'-BIPHENYLDIAMINE FROM P-CHLOROANILINE. EVALUATION OF ANTIFUNGAL AND ANTIOXIDANT ACTIVITIES

Laccase is a copper-containing oxidase that catalyzes reduction of molecular oxygen to water and the oxidation of a phenolic compound. In this paper, laccase was utilized to synthesize 4,4'-Biphenyldiamine using p-chloroaniline as substrate by means of a coupling reaction. The synthesized compo...

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Published inJournal of the Chilean Chemical Society Vol. 61; no. 3; pp. 3031 - 3033
Main Authors CAMPOS, ANA M, MENDOZA, LEONORA, VASQUEZ, JUAN, MELO, RICARDO, SALAS, JENNIFER, COTORAS, MILENA
Format Journal Article
LanguageEnglish
Portuguese
Published Sociedad Chilena de Química 01.09.2016
Subjects
CHEMISTRY, MULTIDISCIPLINARY
p-chloroaniline
antioxidant activity
antifungal activity
laccase
4,4'-Biphenyldiamine
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Summary:Laccase is a copper-containing oxidase that catalyzes reduction of molecular oxygen to water and the oxidation of a phenolic compound. In this paper, laccase was utilized to synthesize 4,4'-Biphenyldiamine using p-chloroaniline as substrate by means of a coupling reaction. The synthesized compound, 4,4'-Biphenyldiamine, presented low antifungal activity against the phytopathogenic fungus Botrytis cinerea, however the antioxidant ability, measurement by ORAC-PGR method, was higher than substrate. This work corresponds to the first report of synthesis 4,4'-Biphenyldiamine, from p-chloroaniline in a lacasse-catalyzed reaction.
ISSN:0717-9707
0717-9707
DOI:10.4067/S0717-97072016000300004