Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease

Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The autho...

Full description

Saved in:
Bibliographic Details
Published inNeurology Vol. 60; no. 7; p. 1189
Main Authors van der Walt, J M, Martin, E R, Scott, W K, Zhang, F, Nance, M A, Watts, R L, Hubble, J P, Haines, J L, Koller, W C, Lyons, K, Pahwa, R, Stern, M B, Colcher, A, Hiner, B C, Jankovic, J, Ondo, W G, Allen, Jr, F H, Goetz, C G, Small, G W, Mastaglia, F, Roses, A D, Stajich, J M, Booze, M W, Fujiwara, K, Gibson, R A, Middleton, L T, Scott, B L, Pericak-Vance, M A, Vance, J M
Format Journal Article
LanguageEnglish
Published United States 08.04.2003
Subjects
Aged
Alleles
Arylamine N-Acetyltransferase - genetics
Chromosomes, Human, Pair 8 - genetics
Female
Gene Frequency
Genetic Linkage
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Isoenzymes - genetics
Male
Middle Aged
Parkinson Disease - enzymology
Parkinson Disease - genetics
Polymorphism, Genetic
Polymorphism, Single Nucleotide - genetics
Risk Assessment
Online AccessGet more information

Cover

More Information
Summary:Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals).
ISSN:1526-632X
DOI:10.1212/01.WNL.0000055929.84668.9A