Duodenal ulcer healing with four antacid tablets daily

In a double-blind, randomized, multicenter trial in 80 consecutive outpatients with endoscopically verified duodenal ulcer, we have tested the ulcer-healing efficacy of a quite low dose of antacids, given only four times daily. The patients received one chewable aluminum-magnesium-antacid tablet (bu...

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Bibliographic Details
Published inScandinavian journal of gastroenterology Vol. 20; no. 9; p. 1041
Main Authors Weberg, R, Berstad, A, Lange, O, Schultz, T, Aubert, E
Format Journal Article
LanguageEnglish
Published England 1985
Subjects
Adult
Aged
Aluminum Hydroxide - therapeutic use
Antacids - administration & dosage
Clinical Trials as Topic
Double-Blind Method
Drug Combinations
Duodenal Ulcer - drug therapy
Female
Humans
Magnesium - therapeutic use
Male
Middle Aged
Random Allocation
Ranitidine - therapeutic use
Tablets
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Summary:In a double-blind, randomized, multicenter trial in 80 consecutive outpatients with endoscopically verified duodenal ulcer, we have tested the ulcer-healing efficacy of a quite low dose of antacids, given only four times daily. The patients received one chewable aluminum-magnesium-antacid tablet (buffering capacity, 30 mmol/tablet) or placebo 1 h after meals and at bedtime. Re-endoscopy after 4 weeks of treatment showed healed ulcer in 28 of 38 patients (74%) in the antacid group, compared with 11 of 38 patients (29%) in the placebo group (p less than 0.001). The number of days and nights with ulcer pain was significantly less in the antacid group than in the placebo group during the treatment period. Thus, only four antacid tablets a day, with a total buffering capacity of 120 mmol/day, significantly promote duodenal ulcer healing and pain relief.
ISSN:0036-5521
DOI:10.3109/00365528509088868