In situ synthesis of a drug-loaded MOF at room temperature

• Published in: Microporous and mesoporous materials Vol. 186; pp. 73 - 79
• Main Authors: Motakef-Kazemi, Negar, Shojaosadati, Seyed Abbas, Morsali, Ali
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.03.2014; Elsevier
• Subjects: Chemistry; Colloidal state and disperse state; Drug delivery; Exact sciences and technology; General and physical chemistry; Ibuprofen; In situ; Porous materials; Zinc; Zn2(1,4-bdc)2(dabco); Zn2(1,4-bdc)2(dabco); Drug delivery; In situ; Zinc; Ibuprofen; Metal organic framework; Drug; Drug carrier; Transition metal; Porous material; Synthesis; Zn; 1,4-bdc; Room temperature; dabco
• ISSN: 1387-1811; 1873-3093
• DOI: 10.1016/j.micromeso.2013.11.036

•In situ synthesis of a ibuprofen-loaded {Zn2(1,4-bdc)2(dabco)}n was studied as a drug delivery system.•The ibuprofen loading efficiency of the MOF was 15% (w/w) in the selected synthesis conditions.•The drug release was also monitored and 80% of the loaded drug was released over 12days. In the present study, in situ synthesis of a drug-loaded metal–organic framework (MOF) was accomplished at room temperature. The produced drug-loaded MOF [{Zn2(1,4-bdc)2(dabco)}n] was then studied as a drug delivery system and exhibited the ability to entrap ibuprofen model drug. The ibuprofen loading efficiency of the MOF was 15% (w/w) in the selected synthesis conditions. The drug release was also monitored and 80% of the loaded drug was released over 12days. The MOF was characterized by IR spectroscopy, X-ray powder diffraction (XRD), thermogravimetric analysis (TGA), UV–vis spectroscopy, N2 adsorption porosimetric (BET), and field emission scanning electron microscopy (FE-SEM). The IC50 value, cytotoxicity, of Zn2(1,4-bdc)2(dabco) for human Hepatoma cell (HuH7) was determined to be 1mg/ml by MTT assay.