Perinatal stroke in term infants with neonatal encephalopathy

In a prospective cohort of 124 encephalopathic term infants, six infants had an acute focal stroke. All six encephalopathic patients with strokes presented with seizures. Neurodevelopmental outcome at 30 months was abnormal in all six patients and significantly worse when compared with the entire co...

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Bibliographic Details
Published inNeurology Vol. 62; no. 11; p. 2088
Main Authors Ramaswamy, V, Miller, S P, Barkovich, A J, Partridge, J C, Ferriero, D M
Format Journal Article
LanguageEnglish
Published United States 08.06.2004
Subjects
Adult
Apgar Score
Brain Damage, Chronic - epidemiology
Brain Damage, Chronic - etiology
Brain Diseases - complications
Brain Diseases - congenital
Cerebral Infarction - epidemiology
Cerebral Infarction - etiology
Cerebral Palsy - epidemiology
Cerebral Palsy - etiology
Cohort Studies
Female
Humans
Infant, Newborn
Magnetic Resonance Imaging
Male
Meconium Aspiration Syndrome - complications
Obstetric Labor Complications - epidemiology
Pregnancy
Pregnancy Complications - epidemiology
Prospective Studies
Risk
Seizures - epidemiology
Seizures - etiology
Severity of Illness Index
Single-Blind Method
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Summary:In a prospective cohort of 124 encephalopathic term infants, six infants had an acute focal stroke. All six encephalopathic patients with strokes presented with seizures. Neurodevelopmental outcome at 30 months was abnormal in all six patients and significantly worse when compared with the entire cohort overall. These findings suggest that in newborns with encephalopathy, acute focal strokes are an uncommon but serious occurrence with substantial risk for abnormal neurodevelopmental outcome.
ISSN:1526-632X
DOI:10.1212/01.WNL.0000129909.77753.C4