Amantadine for the agitated head-injury patient

Traumatic brain injury may be associated with agitated aggressive behaviour and the potential for injury to the patient and staff. We report two cases of recovering brain injury patients with difficult-to-treat destructive behaviour, whose agitation and aggression responded to amantadine. Direct-act...

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Bibliographic Details
Published inBrain injury Vol. 2; no. 4; p. 309
Main Authors Chandler, M C, Barnhill, J L, Gualtieri, C T
Format Journal Article
LanguageEnglish
Published England 1988
Subjects
Adult
Aggression - drug effects
Amantadine - therapeutic use
Brain Damage, Chronic - drug therapy
Brain Injuries - complications
Dose-Response Relationship, Drug
Humans
Male
Neurocognitive Disorders - drug therapy
Psychomotor Agitation - drug therapy
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Summary:Traumatic brain injury may be associated with agitated aggressive behaviour and the potential for injury to the patient and staff. We report two cases of recovering brain injury patients with difficult-to-treat destructive behaviour, whose agitation and aggression responded to amantadine. Direct-acting dopamine agonists such as amantadine may be the preferred treatment for patients with behaviour problems in the acute stages of recovery from coma.
ISSN:0269-9052
DOI:10.3109/02699058809150901