Action of 2-aryliminothiazolidines on octopamine-sensitive adenylate cyclase in the American cockroach nerve cord and on the two-spotted spider mite Tetranychus urticae koch

• Published in: Pesticide biochemistry and physiology Vol. 44; no. 2; pp. 101 - 107
• Main Authors: Hirashima, Akinori, Yoshii, Yutaka, Eto, Morifusa
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 1992; Elsevier
• Subjects: 2-aryliminothiazolidine; adenylate cyclase; Biological and medical sciences; Chemical control; Control; effects on; enzymatic activity; Fundamental and applied biological sciences. Psychology; Invertebrates; Periplaneta americana; Phytopathology. Animal pests. Plant and forest protection; Protozoa. Invertebrates; Tetranychus urticae; Five membered ring; Agonist; Nerve cord; Toxicity; Insecta; Thiazole derivatives; Blattidae; Periplaneta americana; Adenylate cyclase; Acaricide; Pest; Phytophagous; Acari; Enzymatic activity; Oxazole derivatives; Dictyoptera; Oxygen nitrogen heterocycle; Sulfur nitrogen heterocycle; Nuisance; Tetranychidae; Enzyme; Experimental animal; Biological activity; Nervous system physiology; Synanthropic; Acariformes; Arachnida; Tetranychus urticae; Actinedida; Arthropoda; Invertebrata; Octopaminergic receptor
• ISSN: 0048-3575; 1095-9939
• DOI: 10.1016/0048-3575(92)90107-B

The effects of 2-(2,6-diethylphenylimino)thiazolidine (HSO-783) and 2-(4-chloro-2-methylphenylimino)thiazolidine (HSO-786) were compared with those of 2-(2,6-diethylphenylimino)imidazolidine (NC-5) and 2-(4-chloro-2-methylphenylimino)oxazolidine (AC-6) in stimulating adenylate cyclase of Periplaneta americana ventral nerve cord homogenates. These activities were nonadditive with respect to the activity of a maximally effective concentration of octopamine. Washing of homogenates of ventral nerve cord incubated with NC-5, HSO-783, AC-6, and HSO-786 removed nearly all of the stimulatory activities of these agonists. Maximal stimulation of nerve cord adenylate cyclase activity by NC-5, HSO-783, AC-6, and HSO-786 was inhibited by several antagonists, including mianserin, cyproheptadine, chloromazine, and gramine. The rank-order ability of these antagonists to block the maximal adenylate cyclase activation by NC-5, HSO-783, AC-6, and HSO-786 was identical to the rank-order ability of the same antagonists to block the enzyme activation by an optimally effective concentration of octopamine. The β-adrenergic antagonist propranolol was less potent in this respect. AC-6 was a much better acaricide than HSO-783, HSO-786, and NC-5, which were much less potent octopaminergic agonists than AC-6. HSO-786 was a more potent acaricide and octopaminergic agonist than HSO-783. These observations suggest that the toxicity of NC-5, HSO-783, AC-6, and HSO-786 may be due to their octopaminergic agonist action.