Modeling HIV and the infant immune response

Many models have been developed to study the interaction between the human immunodeficiency virus (HIV) virus and an adult's immune system. However, limited work has attempted to explain the interaction between HIV and an infant's immune system. In this study, we introduce a model that con...

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Published inJournal of interdisciplinary mathematics Vol. 13; no. 1; pp. 57 - 76
Main Authors Buenrostro, A., Diaz, K., Gonzales, C. P., Gorritz, M., Verzi, D.W.
Format Journal Article
LanguageEnglish
Published Taylor & Francis Group 01.02.2010
Subjects
CD4
CD8
HIV
Human immunodeficiency virus
immunology
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Summary:Many models have been developed to study the interaction between the human immunodeficiency virus (HIV) virus and an adult's immune system. However, limited work has attempted to explain the interaction between HIV and an infant's immune system. In this study, we introduce a model that considers the dynamics between CD4 + T cells, CD8 + T cells, and the HIV virus. Analysis of the model gives rise to a threshold parameter for the number of new viruses produced by an actively infected CD4 + T cell. Sensitivity analysis and numerical simulations illustrate a variation in the modeled immune response to HIV infection between infants and adults, which may lead to insights for alternative treatments for infants infected with HIV.
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ISSN:0972-0502
2169-012X
DOI:10.1080/09720502.2010.10700678