MoS2/LaF3 for enhanced photothermal therapy performance of poorly-differentiated hepatoma

Photothermal therapy (PTT) based on nanoparticle had been widely used to antitumor treatment. However, low photothermal conversion efficiency (PCE) is the main hurdle for antitumor treatment. To improve the PCE and gain ideal clinical the nanoparticle with higher photothermal conversion efficiency,...

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Published inColloids and surfaces, B, Biointerfaces Vol. 214; p. 112462
Main Authors Sun, Lin, Bai, Huifang, Jiang, Hanjin, Zhang, Peng, Li, Jian, Qiao, Weidong, Wang, Dong, Liu, Guosong, Wang, Xuelin
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.06.2022
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Summary:Photothermal therapy (PTT) based on nanoparticle had been widely used to antitumor treatment. However, low photothermal conversion efficiency (PCE) is the main hurdle for antitumor treatment. To improve the PCE and gain ideal clinical the nanoparticle with higher photothermal conversion efficiency, we have developed a highly efficient solar absorber with MoS2/LaF3/ polydimethylsiloxane(PDMS) which can enhance the absorption of solar irradiation engergy, however, its photothermal effect irradiated by near-infrared light has not yet been investigated. The knowledge absence in photothermal effect will impede MoS2/LaF3/PDMS to be used for cancer therapy in clinic. In this study, we applied LaF3-loaded, MoS2-based photothermal conversion agents (PTAs) for improved photothermal cancer therapy. The study showed that the MoS2/LaF3 nanoflowers showed higher photothermal conversion efficiency (PCE, 42.5%) and could more effectively inhibit cancer cell proliferation compared to MoS2-based PTT agents in vitro. In vivo, the results further revealed that photothermal therapy using MoS2/LaF3 nanoflowers could significantly inhibit solid tumor growth. The study clearly demonstrated that MoS2/LaF3 could work at under low power NIR Laser in vitro and in vivo, resulting in a very impressive therapeutic effect in tumor-bearing mice. The MoS2/LaF3 nanoflowers will be prominent candidate nanoparticle for effective inhibiting tumor growth by photothermal therapy. [Display omitted] •A new NIR photothermal agent was synthesized and characterized.•MoS2/LaF3 nanoflowers was employed to treating poorly-differentiated hepatoma.•MoS2/LaF3 nanoflowers showed higher photothermal conversion efficiency.•This work provided an effective approach inhibiting poorly-differentiated hepatoma.
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ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2022.112462