Methotrexate injection of tubal ectopic pregnancy. A logical evolution?

• Published in: Medical journal of Australia Vol. 154; no. 7; p. 469
• Main Authors: Thompson, G R, O'Shea, R T, Seman, E
• Format: Journal Article
• Language: English
• Published: Australia 01.04.1991
• Subjects: Adult; Chorionic Gonadotropin - blood; Drug Evaluation; Female; Follow-Up Studies; Humans; Injections; Laparoscopy - methods; Methotrexate - administration & dosage; Pregnancy; Pregnancy, Tubal - blood; Pregnancy, Tubal - diagnosis; Pregnancy, Tubal - diagnostic imaging; Pregnancy, Tubal - drug therapy; Prospective Studies; Ultrasonography
• ISSN: 0025-729X
• DOI: 10.5694/j.1326-5377.1991.tb121179.x

To test the efficacy and possible side effects of a single 20 mg dose of methotrexate injected at the time of laparoscopy, in the treatment of tubal ectopic pregnancy. The study was a non-randomised non-blinded prospective clinical trial. The study was carried out at two tertiary referral hospitals. Eighteen patients with unruptured tubal ectopic pregnancies and in a stable haemodynamic condition were offered entry into the study and all of these agreed. At diagnostic laparoscopy, 20 mg of methotrexate in 0.8 mL was injected by fine needle in or around the ectopic gestation. Patients were followed up as outpatients by serial blood tests until resolution of the ectopic pregnancy was demonstrated by a return of the level of beta-human chorionic gonadotrophin to the normal range. There was one failure of treatment. The ectopic pregnancy resolved in the remaining 17 patients. There were no side effects attributable to methotrexate and tubal patency was demonstrated in the eight patients tested by hysterosalpingography.