Asynchronous combined central and peripheral demyelination (CCPD) in a girl with anti-MOG positivity: A case report and review of the literature

• Published in: Journal of neuroimmunology Vol. 384; p. 578213
• Main Authors: Bosisio, Luca, Gastaldi, Matteo, Inglese, Matilde, Rossi, Andrea, Franciotta, Diego, Cataldi, Matteo, Leone, Carmela, Giacomini, Thea, Benedetti, Luana, Nobili, Lino, Mancardi, Maria Margherita
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.11.2023
• Subjects: Acquired demyelinating syndrome - combined central and peripheral demyelination; Anti MOG antibodies; Polyradiculitis; VEP; CBA; NR; MRI; CMAP; CCPD; PNS; ADEM; MADSAM; WM; CSF; EMG; Polyradiculitis; BON; OCBs; MS; CNs; IVIG; AIDP; MOGAD; AEP; CIDP; MMN; SSEPs; Acquired demyelinating syndrome - combined central and peripheral demyelination; IVMP; UON; TM; Anti MOG antibodies; NCS
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/j.jneuroim.2023.578213

The occurrence of combined central and peripheral demyelination (CCPD) is rare, data are limited to small case and cohort studies, mainly concerning adults. In few patients positivity to anti MOG antibody is reported, thus widening the spectrum of anti-MOG associated disorders (MOGAD). We describe a 7-year-old girl with optic neuritis followed 8 years later by peripheral demyelination, with fluctuating anti-MOG antibody positivity at cell-based assay. From the review of the literature, MOGAD-CCPD appear very rare in childhood, especially with asynchronous course. Clinicians should keep this possibility in mind to better define diagnosis in atypical demyelination syndromes, with therapeutical implications.