Pulmonary aspergillosis and central nervous system hemorrhage as complications of autoimmune hemolytic anemia treated with corticosteroids

Warm, active antibody adult autoimmune hemolytic anemia is the most common form of hemolytic anemia not related to drug therapy. Mortality in adult autoimmune hemolytic anemia is related to the inability to successfully treat patients' underlying disease, or the infectious complications of sple...

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Bibliographic Details
Published inSouthern medical journal (Birmingham, Ala.) Vol. 96; no. 6; pp. 592 - 595
Main Authors CLERI, Dennis J, MOSER, Robert L, VILLOTA, Francisco J, YUE WANG, HUSAIN, Syed A, NADEEM, Shahzinah, ANJARI, Tarek, SAJED, Mohammad
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott Williams & Wilkins 01.06.2003
Subjects
Adrenal Cortex Hormones - adverse effects
Adrenal Cortex Hormones - therapeutic use
Adult
Anemia, Hemolytic, Autoimmune - complications
Anemia, Hemolytic, Autoimmune - diagnosis
Anemia, Hemolytic, Autoimmune - drug therapy
Anemias. Hemoglobinopathies
Aspergillosis - diagnosis
Aspergillosis - etiology
Biological and medical sciences
Cerebral Hemorrhage - diagnosis
Cerebral Hemorrhage - etiology
Diseases of red blood cells
Fatal Outcome
Female
Hematologic and hematopoietic diseases
Human mycoses
Humans
Infectious diseases
Lung Diseases, Fungal - diagnosis
Lung Diseases, Fungal - etiology
Medical sciences
Mycoses
Mycoses of the respiratory system
Autoimmunity
Lung disease
Corticosteroid
Mycosis
Respiratory disease
Central nervous system
Hemopathy
Hemorrhage
Infection
Hemolytic anemia
Treatment
Pulmonary aspergillosis
Autoimmune hemolytic anemia
Complication
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Summary:Warm, active antibody adult autoimmune hemolytic anemia is the most common form of hemolytic anemia not related to drug therapy. Mortality in adult autoimmune hemolytic anemia is related to the inability to successfully treat patients' underlying disease, or the infectious complications of splenectomy and prolonged steroid therapy. Predisposing factors for invasive aspergillosis are neutropenia and steroid therapy. We present a fatal case of aspergillosis complicating a nonneutropenic case of warm active antibody adult autoimmune hemolytic anemia treated with prolonged steroid therapy.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0038-4348
1541-8243
DOI:10.1097/01.SMJ.0000056645.47125.96