Chemical Constituents from Branches of Maytenus gonoclada (Celastraceae) and Evaluation of Antimicrobial Activity

Six pentacyclic triterpenes were isolated from branches of Maytenus gonoclada (Celastraceae) and all NMR data of a new compound 3-oxo-12 alpha,29-dihydroxyfriedelane are herein reported. The stereochemistry of the new friedelane was established by bidimensional NMR (HSQC, HMBC and NOESY) data, and i...

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Published inJournal of the Brazilian Chemical Society Vol. 22; no. 5; pp. 943 - U190
Main Authors Silva, Fernando C., Duarte, Lucienir P., Silva, Gracia D. F., Filho, Sidney A. V., Lula, Ivana S., Takahashi, Jacqueline A., Sallum, William S. T.
Format Journal Article
LanguageEnglish
Published SAO PAULO Soc Brasileira Quimica 01.05.2011
Sociedade Brasileira de Química
Subjects
Chemistry
CHEMISTRY, MULTIDISCIPLINARY
Physical Sciences
Science & Technology
3-oxo-12 alpha-hydroxyfriedelane
C-13
ESSENTIAL OILS
ANTIBACTERIAL ACTIVITY
Celastraceae
3-oxo-12 alpha,29-dihydroxyfriedelane
PENTACYCLIC TRITERPENOIDS
antimicrobial activity
SPECTRA
H-1
Maytenus gonoclada
ASSIGNMENTS
3-oxo-12α-hydroxyfriedelane
3-oxo-12α,29-dihydroxyfriedelane
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Summary:Six pentacyclic triterpenes were isolated from branches of Maytenus gonoclada (Celastraceae) and all NMR data of a new compound 3-oxo-12 alpha,29-dihydroxyfriedelane are herein reported. The stereochemistry of the new friedelane was established by bidimensional NMR (HSQC, HMBC and NOESY) data, and its molecular weight confirmed by ESI mass spectrometry. Antimicrobial activity assays using the method of disk diffusion and macrodilution were carried out against the bacteria Escherichia coli, Citrobacter freundii, and Bacillus cereus, and against the fungi Candida albicans. The triterpene 3-oxo-12 alpha-hydroxyfriedelane showed positive result against C. albicans.
ISSN:0103-5053
1678-4790
1678-4790
DOI:10.1590/S0103-50532011000500018