Surfactant-modified clinoptilolite as a salicylate carrier, salicylate kinetic release and its antibacterial activity

• Published in: Microporous and mesoporous materials Vol. 159; pp. 30 - 35
• Main Authors: JEVTIC, Sanja, GRUJIC, Svetlana, HRENOVIC, Jasna, RAJIC, Nevenka
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.09.2012; Elsevier
• Subjects: Antibacterial activity; Bacteria; Chemistry; Clinoptilolite; Colloidal state and disperse state; Exact sciences and technology; General and physical chemistry; Ion-exchange; Kinetic release; Porous materials; Salicylate; Surface physical chemistry; Zeolites: preparations and properties; Kinetic release; Clinoptilolite; Salicylate; Bacteria; Antibacterial activity; Drug; Modification; Cationic surfactant; Zeolite; Acetylsalicylic acid; Surfactant; Ionic surfactant; Porous material; Molecular sieve; Composite material; Adsorption; Chlorides; Models; Kinetics; Aqueous solution; Antibacterial agent; Release
• ISSN: 1387-1811; 1873-3093
• DOI: 10.1016/j.micromeso.2012.04.014

E. coli at the surface of salicylate-containing clinoptilolite. The material with simultaneous antibacterial and anti-inflammatory effects. [Display omitted] ► Surfactant-modified clinoptilolite is suitable carrier for salicylate ion. ► Slow release salicylate ion from clinoptilolite surface. ► Salicylate-containing clinoptilolite: simultaneous antibacterial and anti-inflammatory drug. The cationic surfactant benzalkonium chloride (BC) was used for modification of the natural clinoptilolite surface in order to prepare a suitable carrier for the salicylate anion. The salicylate-containing clinoptilolite composite was prepared by adsorption from an aqueous aspirin solution. The composite releases salicylate in two stages: about 50% of the adsorbed salicylate is delivered in the first 15min and an additional 30% is released slowly within the next 5h. The Korsmeyer–Peppas model best describes the release profile. Both the BC-modified clinoptilolite and the salicylate-containing product were tested against Escherichia coli and Staphylococcus aureus. The results indicate that the salicylate-containing material may represent an alternative drug having simultaneous antibacterial and anti-inflammatory effects.