The association between plasma N-terminal pro-brain natriuretic peptide concentration and metabolic disturbances in women with depressive symptoms

• Published in: Psychoneuroendocrinology Vol. 158; p. 106409
• Main Authors: Łapińska, Lidia, Krentowska, Anna, Kondraciuk, Marcin, Chlabicz, Małgorzata, Waszkiewicz, Napoleon, Kamiński, Karol, Kowalska, Irina
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2023
• Subjects: Depressive symptoms; Insulin resistance; Metabolic syndrome; NT-proBNP; Depressive symptoms; Insulin resistance; NT-proBNP; Metabolic syndrome
• ISSN: 0306-4530; 1873-3360
• DOI: 10.1016/j.psyneuen.2023.106409

The relationship between brain natriuretic peptides and depression was studied in patients with cardiovascular diseases (CVD), but the data in people without CVD are limited. Metabolic disturbances can be associated with natriuretic peptides’ levels. The study aimed to assess serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level in women with depressive symptoms and its relationship with metabolic disturbances. The analysis included 347 women (20–60 years old) from Bialystok PLUS cohort study: 98 with depressive symptoms and 249 controls. Clinical examination, oral glucose tolerance test (OGTT) and assessment of lipid, sex hormone binding globulin (SHBG) and NT-proBNP concentrations in the blood were performed. The participants completed Beck Depression Inventory questionnaire. Metabolic syndrome was more frequent in the group of women with depressive symptoms compared to women without depressive symptoms. Women with depressive symptoms had lower NT-proBNP level than the control group - 45.88 (27.80–67.04) vs 56.49 (32.42–94.25) pg/mL, p = 0.027. Multiple linear regression analysis of all women showed that NT-proBNP level was reversely associated with the presence of depressive symptoms, waist circumference and heart rate and positively connected with age. In the group of women with depressive symptoms, we observed negative correlations between NT-proBNP level and insulin concentration at 60 min of OGTT, diastolic blood pressure and a positive correlation with SHBG. NT-proBNP level is decreased in women with depressive symptoms, which might be connected with metabolic disturbances in this group. •Metabolic syndrome occurs frequently in women with depressive symptoms.•Presence of depressive symptoms in women is connected with low N-terminal pro-brain natriuretic peptide level (NT-proBNP).•NT-proBNP level is related with metabolic parameters, especially with indirect indices of insulin resistance.