External Application of a Nomogram to Predict Survival and Benefit of Peripheral Blood Inflammatory Indexes in Limited-Stage Small Cell Lung Cancer

• Published in: Frontiers in oncology Vol. 12; p. 873367
• Main Authors: Wei, Lijuan, Hou, Qing, Liu, Jianting, Yao, Ningning, Liang, Yu, Cao, Xin, Sun, Bochen, Li, Hongwei, Xu, Shuming, Cao, Jianzhong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.05.2022
• Subjects: external application; immune and inflammatory; Oncology; overall survival; prognoses prediction; small cell lung cancer; external application; overall survival; immune and inflammatory; small cell lung cancer; prognoses prediction
• ISSN: 2234-943X; 2234-943X
• DOI: 10.3389/fonc.2022.873367

Qi et al. recently proposed a nomogram to reveal the prognostic value of peripheral blood inflammatory indexes (named Risk) and predict overall survival (OS) in limited-stage small cell lung cancer (LS-SCLC). However, it hasn't undergone external application so far. This study aimed to verify the role of Risk as a prognostic variable of OS and apply the nomogram externally. We used a retrospective analysis of clinical data of 254 patients diagnosed as LS-SCLC in Shanxi Cancer Hospital from January 2015 to December 2018 to apply Qi's nomogram externally. We also performed subgroup analysis to explore the predictive value of Risk. The model was evaluated in terms of discrimination (the area under the ROC curve (AUC ROC) and calibration (calibration plots). The prognosis of patients with low-Risk was significantly better than those with high-Risk in our cohort (p<0.01). The AUC of 1-, 2-, and 3-year OS was 0.644, 0.666, and 0.635, respectively. The calibration curve showed a nearly ideal calibration-slope of 1-, 2-, and 3-year OS (1.00 (0.41-1.59), 1.00 (0.54-1.46) and 1.00 (0.43-1.57), respectively). The external application of nomogram added Risk for predicting OS in LS-SCLC patients showed a moderate-to-good performance using a cohort with different case-mix characteristics. The external application confirmed the predictive value of Risk and the usefulness of the nomogram for the prediction of OS.