Experience with metrizamide in patients with previous severe anaphylactoid reactions to ionic contrast agents

Metrizamide was employed in six patients who, during angiography, had had severe anaphylactoid reactions to conventional ionic contrast media. Five of these patients had received corticoid premedication before injection of both conventional contrast medium and metrizamide; anaphylaxis occurred only...

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Published inRadiology Vol. 143; no. 2; p. 321
Main Authors Rapoport, S, Bookstein, J J, Higgins, C B, Carey, P H, Sovak, M, Lasser, E C
Format Journal Article
LanguageEnglish
Published United States 01.05.1982
Subjects
Adolescent
Adult
Aged
Anaphylaxis - chemically induced
Angiography
Child
Contrast Media - adverse effects
Edema - chemically induced
Female
Humans
Male
Metrizamide - toxicity
Osmolar Concentration
Prednisone - therapeutic use
Premedication
Tachycardia - chemically induced
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Summary:Metrizamide was employed in six patients who, during angiography, had had severe anaphylactoid reactions to conventional ionic contrast media. Five of these patients had received corticoid premedication before injection of both conventional contrast medium and metrizamide; anaphylaxis occurred only after administration of conventional contrast media. Four patients had no detectable reaction whatsoever after metrizamide; a fifth had only transient tachycardia. In the sixth patient, delayed edema developed in the region of his cerebral arteriovenous malformation. These observations suggest a marked decrease in the incidence and severity of anaphylactoid reactions when metrizamide is substituted in patients who have reacted to ionic contrast media. Metrizamide, or a comparable nonionic contrast agent, should be strongly considered in patients who have had a severe reaction to conventional contrast medium.
ISSN:0033-8419
DOI:10.1148/radiology.143.2.7071332