Bilateral volume reduction of the superior temporal areas in Landau-Kleffner syndrome

No specific anatomic abnormalities have been detected in typical Landau-Kleffner syndrome (LKS), an acquired epileptic aphasia with language regression in children. In four children with typical LKS without obvious anatomic abnormalities, the authors performed MRI volumetric analysis of various neoc...

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Bibliographic Details
Published inNeurology Vol. 63; no. 7; p. 1289
Main Authors Takeoka, M, Riviello, Jr, J J, Duffy, F H, Kim, F, Kennedy, D N, Makris, N, Caviness, Jr, V S, Holmes, G L
Format Journal Article
LanguageEnglish
Published United States 12.10.2004
Subjects
Auditory Cortex - pathology
Case-Control Studies
Cerebral Cortex - pathology
Child
Child, Preschool
Female
Humans
Landau-Kleffner Syndrome - pathology
Magnetic Resonance Imaging
Male
Neocortex - pathology
Organ Size
Temporal Lobe - pathology
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Summary:No specific anatomic abnormalities have been detected in typical Landau-Kleffner syndrome (LKS), an acquired epileptic aphasia with language regression in children. In four children with typical LKS without obvious anatomic abnormalities, the authors performed MRI volumetric analysis of various neocortical regions and subcortical substructures. Volume reduction was detected in bilateral superior temporal areas (26 to 51%), specifically in planum temporale (25 to 63%) and superior temporal gyrus (25 to 57%), where receptive language is localized.
ISSN:1526-632X
DOI:10.1212/01.WNL.0000140703.63270.9D