Advancements in research on lactate dehydrogenase A in urinary system tumors

• Published in: BMC urology Vol. 24; no. 1; pp. 187 - 8
• Main Authors: Zhuo, Zhiyuan, Wang, Yu, Xu, Yifan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.08.2024; BioMed Central; BMC
• Subjects: Autophagy; Biomarkers; Biomedical Research; Bladder cancer; Cancer; Dehydrogenases; Development and progression; Disease; Energy; Glucose; Glucose metabolism; Glycolysis; Humans; Hypoxia; Isoenzymes - urine; Kidney cancer; L-Lactate dehydrogenase; L-Lactate Dehydrogenase - urine; Lactate Dehydrogenase 5; Lactic acid; Male; Medical prognosis; Metabolism; Metastases; Metastasis; Phosphorylation; Physical fitness; Physiology; Prostate cancer; Prostate carcinoma; Renal cell carcinoma; Tumors; Urinary Bladder Neoplasms - diagnosis; Urologic Neoplasms - diagnosis
• ISSN: 1471-2490; 1471-2490
• DOI: 10.1186/s12894-024-01580-y

Tumors of the urinary system, such as prostate cancer, bladder cancer, and renal cell carcinoma, are among the most prevalent types of tumors. They often remain asymptomatic in their early stages, with some patients experiencing recurrence or metastasis post-surgery, leading to disease progression. Lactate dehydrogenase A (LDHA) plays a crucial role in the glycolysis pathway and is closely associated with anaerobic glycolysis in urinary system tumors. Therefore, a comprehensive investigation into the intricate mechanism of LDHA in these tumors can establish a theoretical foundation for early diagnosis and advanced treatment. This review consolidates the current research and applications of LDHA in urinary system tumors, with the aim of providing researchers with a distinct perspective.