Antihypertensive effect of methanolic extract of Passiflora nepalensis

The present study was designed to investigate the antihypertensive effect of methanolic extract of the whole plant of Passiflora nepalensis Walp., Passifloraceae, (MPN) in renal hypertensive and normotensive rats. The blood pressure, pulse pressure, and heart rate fell dose-dependently in renal hype...

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Published inRevista brasileira de farmacognosia Vol. 21; no. 1; pp. 187 - 189
Main Authors Patel, Sita Sharan, Verma, Neelesh Kumar, Shrestha, Bhupendra, Gauthaman, Karunakaran
Format Journal Article
LanguageEnglish
Portuguese
Published Sociedade Brasileira de Farmacognosia 01.02.2011
Subjects
PHARMACOLOGY & PHARMACY
antihypertensive effect
heart rate
Passiflora nepalensis
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Summary:The present study was designed to investigate the antihypertensive effect of methanolic extract of the whole plant of Passiflora nepalensis Walp., Passifloraceae, (MPN) in renal hypertensive and normotensive rats. The blood pressure, pulse pressure, and heart rate fell dose-dependently in renal hypertensive and normotensive rats after intravenous administration of 75, 150, and 225 mg/kg MPN, suggesting that MPN possesses antihypertensive, hypotensive and negative chronotropic effects. The effect at doses of 150 and 225 mg/kg of MPN were more pronounced than that of 75 mg/kg body weight. Thus, the present study reveals that MPN exerts antihypertensive effect against renal hypertension.
ISSN:0102-695X
1981-528X
DOI:10.1590/S0102-695X2011005000012