The toxicity evaluation of Syzygium cumini leaves in rodents

• Published in: Revista brasileira de farmacognosia Vol. 22; no. 1; pp. 102 - 108
• Main Authors: Silva, Selma do N., Abreu, Iracelle C., Silva, Graciela Fernanda C., Ribeiro, Rachel M., Lopes, Adelson de S., Cartágenes, Maria do Socorro de S., Freire, Sônia Maria de F., Borges, Antônio Carlos R., Borges, Marilene Oliveira da R.
• Format: Journal Article
• Language: English
• Published: Sociedade Brasileira de Farmacognosia 01.02.2012
• Subjects: PHARMACOLOGY & PHARMACY; acute and chronic toxicity; biochemical parameters; histology; haematologic parameters; Syzygium cumini (L.) Skeels
• ISSN: 0102-695X; 1981-528X
• DOI: 10.1590/S0102-695X2011005000181

This study aimed to evaluate the safety of the hydroalcoholic extract (HE) of Syzygium cumini (L.) Skeels, Myrtaceae, leaves in rodents. Acute toxicity was evaluated through the determination of a LD50 in mice and rats (up to 14 days). In mice, the oral administration (p.o.) of the HE (0.1 at 6 g/kg) did not cause any death. When administered by intraperitoneal route (i.p.) the HE (0.1 at 1 g/kg) caused death of the animals (LD50 of 0.489 g/kg). In rats, the HE (0.5, 1 and 2 g/kg, p.o.) did not cause any death, while by i.p., only the 2 g/kg dose was lethal to 67% of the animals. To evaluate chronic toxicity, groups of rats daily received the HE (0.05, 0.1 and 0.25 g/kg) through p.o., during 30, 90 or 180 days and the effects on behavior, body weight, feed consumed were measured. Histology, hematology and biochemical parameters were measured at the end of the treatment. After a 30-day treatment, the HE caused changes in some biochemical parameters. Histological examination of the liver, kidneys, lungs, heart, stomach, intestine and pancreas showed normal architecture suggesting no morphological disturbances. These data may mean that the HE of S. cumini does not exert acute or chronic toxic effects by oral administration.