Polypropylene composite mesh modified by polyurethane gel with ROS scavenging and anti-inflammatory effects for pelvic floor repair

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 230; p. 113518
• Main Authors: Wang, Xiaofei, Wei, Hongxiu, Ou, Yangcen, Li, Zhen, Luo, Feng, Tan, Hong, Li, Jiehua
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2023
• Subjects: Inflammation; Polypropylene mesh; Polyurethane; Reactive oxygen species; Surface modification; Polypropylene mesh; Surface modification; Reactive oxygen species; Inflammation; Polyurethane
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2023.113518

Development of an inflammation modulating polypropylene (PP) mesh in pelvic floor repair is an urgent clinical need. This is because PP mesh for pelvic floor repair can cause a series of complications related to foreign body reactions (FBR) in postoperative period. Therefore, we successfully prepared PP composite mesh that can scavenge reactive oxygen species (ROS) and inhibit inflammation to moderate FBR by a simple method. First, a pregel layer was formed on PP mesh by dip coating. Among them, polyurethane with polythioketal (PTK) is an excellent ROS scavenger, and dopamine methacrylamide (DMA) improves the stability of the coating and synergistically scavenges ROS. Then, a composite mesh (optimal PU50-PP) was obtained by photopolymerization. The results showed that the polyurethane gel layer was able to scavenge more than 90% of free radicals and about 75% of intracellular ROS. In vitro, PU50-PP mesh significantly scavenged ROS and resisted macrophage adhesion. After implantation in the posterior vaginal wall of rats, PU50-PP eliminated 53% of ROS, inhibited inflammation (decreased IL-6, increased IL-10), and dramatically reduced collagen deposition by about 64%, compared to PP mesh. Thus, the composite PP mesh with ROS scavenging and anti-inflammatory properties provides a promising approach for mitigating FBR. •Modification of polypropylene mesh with ROS-scavenging polyurethane gel.•Preparation of modified polypropylene mesh by simple ultraviolet curing.•The modified mesh has excellent ROS scavenging and anti-inflammatory properties.•Good anti-inflammatory effects make this mesh a candidate for pelvic floor repair.