Hypochlorite activated poly(N-isopropylacrylamide)-core poly(N-isopropylmethacrylamide)-shell microgels—An oxidant with the potential to kill cells

•Poly(N-isopropylacrylamide), NIPAM, forms chloramides in bleach whereas poly(N-isopropylmethacrylamide), PNIPMAM, does not.•Chlorinated PNIPAM-core/PNIPMAM-shell microgels are colloidally stable.•Chlorinated microgels serve as a depot of active chlorine with the potential for targeted cell killing....

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Bibliographic Details
Published inColloids and surfaces. A, Physicochemical and engineering aspects Vol. 457; pp. 340 - 344
Main Authors Wang, Zuohe, Hart, Erica, Pelton, Robert
Format Journal Article
LanguageEnglish
Published Elsevier B.V 05.09.2014
Subjects
Chloramide
Chlorination
Colloids
Core/shell
Glutathione
Microgel
Microgels
Oxidants
Phosphates
Redox
Shells
Stabilization
Steric stabilization
Redox
Microgel
Core/shell
Steric stabilization
Chloramide
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Summary:•Poly(N-isopropylacrylamide), NIPAM, forms chloramides in bleach whereas poly(N-isopropylmethacrylamide), PNIPMAM, does not.•Chlorinated PNIPAM-core/PNIPMAM-shell microgels are colloidally stable.•Chlorinated microgels serve as a depot of active chlorine with the potential for targeted cell killing. Poly(N-isopropylacrylamide) (PNIPAM) core/poly(N-isopropylmethacrylamide) (PNIPMAM) shell microgels react with dilute alkaline bleach, forming chloramides primarily in the PNIPAM core. The resulting microgels are colloidally stable in PBS (phosphate buffered saline) at body temperature because the PNIPMAM shell provides steric stabilization. Selective chloramide formation of the PNIPAM cores reflects the low tendency of the PNIPMAM shell to react with hypochlorite. The chlorinated core/shell microgels can be cleaned and stored. Because PNIPAM chloramide can oxidize 2-mercaptoethanol and glutathione, the chlorinated core/shell microgels may have applications in targeted cell death.
Bibliography:ObjectType-Article-2
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ISSN:0927-7757
1873-4359
DOI:10.1016/j.colsurfa.2014.05.065