Hypochlorite activated poly(N-isopropylacrylamide)-core poly(N-isopropylmethacrylamide)-shell microgels—An oxidant with the potential to kill cells
•Poly(N-isopropylacrylamide), NIPAM, forms chloramides in bleach whereas poly(N-isopropylmethacrylamide), PNIPMAM, does not.•Chlorinated PNIPAM-core/PNIPMAM-shell microgels are colloidally stable.•Chlorinated microgels serve as a depot of active chlorine with the potential for targeted cell killing....
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Published in | Colloids and surfaces. A, Physicochemical and engineering aspects Vol. 457; pp. 340 - 344 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
05.09.2014
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Subjects | |
Online Access | Get full text |
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Summary: | •Poly(N-isopropylacrylamide), NIPAM, forms chloramides in bleach whereas poly(N-isopropylmethacrylamide), PNIPMAM, does not.•Chlorinated PNIPAM-core/PNIPMAM-shell microgels are colloidally stable.•Chlorinated microgels serve as a depot of active chlorine with the potential for targeted cell killing.
Poly(N-isopropylacrylamide) (PNIPAM) core/poly(N-isopropylmethacrylamide) (PNIPMAM) shell microgels react with dilute alkaline bleach, forming chloramides primarily in the PNIPAM core. The resulting microgels are colloidally stable in PBS (phosphate buffered saline) at body temperature because the PNIPMAM shell provides steric stabilization. Selective chloramide formation of the PNIPAM cores reflects the low tendency of the PNIPMAM shell to react with hypochlorite. The chlorinated core/shell microgels can be cleaned and stored. Because PNIPAM chloramide can oxidize 2-mercaptoethanol and glutathione, the chlorinated core/shell microgels may have applications in targeted cell death. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0927-7757 1873-4359 |
DOI: | 10.1016/j.colsurfa.2014.05.065 |