Role of myristoylation in the intracellular targeting of neuronal calcium sensor (NCS) proteins

The control of the intracellular localization of NCS (neuronal calcium sensor) proteins is of importance for their ability to respond appropriately to differing calcium signals. We examine the localization of three NCS proteins: NCS-1, KChIP-1 (potassium-channel-interacting protein 1) and hippocalci...

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Bibliographic Details
Published inBiochemical Society transactions Vol. 31; no. Pt 5; p. 963
Main Authors O'Callaghan, D W, Burgoyne, R D
Format Journal Article
LanguageEnglish
Published England 01.10.2003
Subjects
Animals
Calcium - metabolism
Calcium-Binding Proteins - chemistry
Calcium-Binding Proteins - metabolism
Hippocalcin
Humans
Models, Biological
Myristic Acids - metabolism
Nerve Tissue Proteins
Neuronal Calcium-Sensor Proteins
Neurons - metabolism
Neuropeptides - metabolism
Protein Binding
Protein Transport
Signal Transduction
Time Factors
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Summary:The control of the intracellular localization of NCS (neuronal calcium sensor) proteins is of importance for their ability to respond appropriately to differing calcium signals. We examine the localization of three NCS proteins: NCS-1, KChIP-1 (potassium-channel-interacting protein 1) and hippocalcin. Additionally, the [Ca(2+)] dependency of the calcium-induced translocation of hippocalcin is investigated. The implications of the differential targeting of these proteins on calcium signal interpretation are considered.
ISSN:0300-5127
DOI:10.1042/bst0310963