In vivo hyperthermia effect induced by high-intensity pulsed ultrasound

Hyperthermia effects （39-44 ℃） induced by pulsed high-intensity focused ultrasound （HIFU） have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into a solid tumor. However, previous studies also reported that the cell death occurs when cells are...

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Bibliographic Details
Published inChinese physics B Vol. 21; no. 7; pp. 352 - 358
Main Author 崔炜程 屠娟 Hwang Joo-Ha 李倩 范庭波 章东 陈静海 陈伟中
Format Journal Article
LanguageEnglish
Published 01.07.2012
Subjects
Biocompatibility
Biomedical materials
Blood vessels
Constants
HIFU
Hyperthermia
In vivo testing
In vivo tests
Surgical implants
Ultrasound
体内
占空比
热疗
细胞死亡
脉冲重复频率
诱导效应
高强度聚焦超声
Online AccessGet full text
ISSN1674-1056
2058-3834
1741-4199
DOI10.1088/1674-1056/21/7/074301

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Summary:Hyperthermia effects （39-44 ℃） induced by pulsed high-intensity focused ultrasound （HIFU） have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into a solid tumor. However, previous studies also reported that the cell death occurs when cells are maintained at 43 ℃ for more than 20 minutes. The aim of this study is to investigate thermal responses inside in vivo rabbit auricular veins exposed to pulsed HIFU （1.17 MHz, 5300 W/cm2, with relatively low-duty ratios （0.2%-4.3%）. The results show that： （1） with constant pulse repetition frequency （PRF） （e.g., 1 Hz）, the thermal responses inside the vessel will increase with the increasing duty ratio; （2） a temperature elevation to 43 ℃ can be identified at the duty ratio of 4.3%; （3） with constant duty ratios, the change of PRF will not significantly affect the temperature measurement in the vessel; （4） as the duty ratios lower than 4.3%, the presence of microbubbles will not significantly enhance the thermal responses in the vessel, but will facilitate HIFU-induced inertial cavitation events.
Bibliography:Cui Wei-Cheng, Tu Juan, Hwang Joo-Ha, Li Qian , Fan Ting-Bo, Zhang Dong Chen Jing-Hai, and Chen Wei-ZhongKey Laboratory of Modern Acoustics, MOE, and Institute of Acoustics, Nanjing University, Nanjing 210093, C b） Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 98105, USA C） Department of Cardiology of Children＇s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Hyperthermia effects （39-44 ℃） induced by pulsed high-intensity focused ultrasound （HIFU） have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into a solid tumor. However, previous studies also reported that the cell death occurs when cells are maintained at 43 ℃ for more than 20 minutes. The aim of this study is to investigate thermal responses inside in vivo rabbit auricular veins exposed to pulsed HIFU （1.17 MHz, 5300 W/cm2, with relatively low-duty ratios （0.2%-4.3%）. The results show that： （1） with constant pulse repetition frequency （PRF） （e.g., 1 Hz）, the thermal responses inside the vessel will increase with the increasing duty ratio; （2） a temperature elevation to 43 ℃ can be identified at the duty ratio of 4.3%; （3） with constant duty ratios, the change of PRF will not significantly affect the temperature measurement in the vessel; （4） as the duty ratios lower than 4.3%, the presence of microbubbles will not significantly enhance the thermal responses in the vessel, but will facilitate HIFU-induced inertial cavitation events.
11-5639/O4
hyperthermia effects, high-intensity focused ultrasound, duty ratio, ultrasound contrastagents
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ISSN:1674-1056
2058-3834
1741-4199
DOI:10.1088/1674-1056/21/7/074301