Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water

In this work, an analytical method based on solid phase extraction (SPE) and liquid chromatography tandem mass spectrometry (LC-APCI-MS/MS) was developed and validated for the determination and confirmation of five pharmaceuticals in water samples. The limits of detection (LOD) ranged from 0.053 to...

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Bibliographic Details
Published inJournal of the Brazilian Chemical Society Vol. 22; no. 10; pp. 1944 - 1952
Main Authors Cardoso, Liziane V., Tomasini, Débora, Sampaio, Maicon R. F., Caldas, Sergiane S., Kleemann, Natiele, Primel, Ednei G., Gonçalves, Fabio F.
Format Journal Article
LanguageEnglish
Published Sociedade Brasileira de Química 01.10.2011
Subjects
CHEMISTRY, MULTIDISCIPLINARY
method validation
SPE
emergent contaminants
LC-APCI-MS/MS
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Summary:In this work, an analytical method based on solid phase extraction (SPE) and liquid chromatography tandem mass spectrometry (LC-APCI-MS/MS) was developed and validated for the determination and confirmation of five pharmaceuticals in water samples. The limits of detection (LOD) ranged from 0.053 to 0.53 µg L-1 and the limits of quantification (LOQ) from 0.16 to 1.6 µg L-1. Good linearity was obtained with r > 0.99 for all compounds. The recoveries of the compounds ranged from 70 to 120% with relative standard deviations (RSD) below 20% for all. Through multiple reactions monitoring (MRM) two different transitions, precursor ion-product ion, were selected for each pharmaceutical.
ISSN:0103-5053
1678-4790
DOI:10.1590/S0103-50532011001000016