Changes in immunoexpression of E-cadherin and β -catenin in oral squamous cell carcinoma with and without nodal metastasis

• Published in: Annals of diagnostic pathology Vol. 13; no. 1; pp. 22 - 29
• Main Authors: Lopes, Fernanda Ferreira, da Costa Miguel, Márcia Cristina, Pereira, Antônio Luiz Amaral, da Cruz, Maria Carmen Fontoura Nogueira, de Almeida Freitas, Roseana, Pinto, Leão Pereira, de Souza, Lélia Batista
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2009
• Subjects: Adult; Aged; Aged, 80 and over; beta Catenin - analysis; Cadherins - analysis; Carcinoma, Squamous Cell - chemistry; Carcinoma, Squamous Cell - pathology; Cell Membrane - chemistry; Cell Nucleus - chemistry; Cytoplasm - chemistry; E-cadherin; Female; Humans; Immunohistochemistry; Lip - chemistry; Lip - pathology; Lip Neoplasms - chemistry; Lip Neoplasms - pathology; Lymphatic Metastasis; Male; Middle Aged; Oral cancer; Pathology; Squamous cell carcinoma; Tongue - chemistry; Tongue - pathology; Tongue Neoplasms - chemistry; Tongue Neoplasms - pathology; β-catenin; Immunohistochemistry; β-catenin; Squamous cell carcinoma; Oral cancer; E-cadherin
• ISSN: 1092-9134; 1532-8198
• DOI: 10.1016/j.anndiagpath.2008.07.006

Abstract The aim of this study is to analyze the immunohistochemical expression of E-cadherin and β -catenin in oral squamous cell carcinoma to better understand the biological behavior of this lesion. The sample consisted of 15 cases of the tongue and 15 of the lower lip. The pattern and intensity of the labeling and the analysis of the percentage of tumor cells immunopositive in membrane for E-cadherin and β -catenin were related to the anatomic location of the lesion, the presence or absence of nodal metastasis, and the histological gradation of malignancy in the tumor invasion front. The presence or absence of cytoplasmic and nuclear labeling was also recorded. The membrane expression for E-cadherin and β -catenin predominately displayed a heterogeneous pattern in the carcinomas studied. No significant difference was observed between the expression pattern and the quantity of cells immunopositive for E-cadherin and β -catenin and the anatomic location of the lesion or the presence or absence of nodal metastasis. However, a statistically significant difference was found between the reduced expressio\n of these proteins and the high malignancy score. The reduced immunoexpression of these proteins in the membrane may be related to the high degree of cell indifferentiation in cases of oral squamous cell carcinoma with high scores.