Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases

• Published in: Biomedical and environmental sciences Vol. 24; no. 5; pp. 491 - 498
• Main Authors: PAN, ShangXia, YANG, XingFen, YANG, LinQing, WEI, Qing, YANG, Ying, XU, GuangNing, LIN, ZhongNing, HUANG, JunMing
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.10.2011; Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 510300, Guangdong, China%School of Public Health, Sun Yat-Sen University, Guangzhou 510080, Guangdong, China
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Alcohol Drinking - genetics; Asian Continental Ancestry Group - genetics; China - ethnology; Female; Genetic polymorphism; Genetic Predisposition to Disease; Glutathione Transferase - genetics; Glutathione-S-transferases; GSTs; Humans; Hypertension - genetics; Logistic回归分析; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Smoking - genetics; The Hakka; Young Adult; 中国南方; 客家人; 家族史; 慢性疾病; 遗传多态性; 限制性片段长度多态性分析; China; Glutathione-S-transferases; The Hakka; Genetic polymorphism; Glutathione-S- transferases
• ISSN: 0895-3988; 2214-0190
• DOI: 10.3967/0895-3988.2011.05.006

Objective To investigate the associations of genetic polymorphisms in GSTs genes of the Hakka population of south China with family histories of certain chronic diseases.Methods Five hundred and thirty‐nine healthy Hakka natives of Meizhou city of Guangdong province in south China were involved.The genotypes of GSTM1,GSTT1,GSTP1,GSTM3,and GSTA1 were determined using PCR and restriction fragment length polymorphism analysis.The observed polymorphisms were analyzed by Chi‐square and Hardy‐Weinberg equilibrium tests.Logistic regression analysis was used to determine the associations of the distributions of GST genotypes with family history of certain chronic diseases.Results The distributions of polymorphisms in GSTP1,GSTM3,and GSTA1 conformed to the Hardy‐Weinberg equilibrium.Compared to the Cantonese,the Hakka had a lower distribution of the GSTM3 deletion genotype （3.15% vs.11.9%）.A weak association was observed between the GSTM1 genetic polymorphism and family history of hypertension.Alcohol drinkers had a higher frequency of the null‐GSTM1 genotype,while smokers had a higher frequency of a variant GSTP1 genotype.Conclusion The results suggest that the Hakka is a special and distinctive Han Chinese ethnic group with different GSTs genetic polymorphisms.Smoking and drinking might be related to the distribution of GST genotypes.