Estrogen exposures and memory at midlife: a population-based study of women

Estrogen loss after natural menopause is hypothesized to impair episodic memory. A total of 326 women aged 52 to 63 years participating in the Melbourne Women's Midlife Health Project completed a word list memory task. Estrogen exposures were inferred from menopausal status, time from final men...

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Bibliographic Details
Published inNeurology Vol. 60; no. 8; p. 1369
Main Authors Henderson, V W, Guthrie, J R, Dudley, E C, Burger, H G, Dennerstein, L
Format Journal Article
LanguageEnglish
Published United States 22.04.2003
Subjects
Body Mass Index
Cohort Studies
Estradiol - blood
Estrogen Replacement Therapy
Estrogens - pharmacology
Estrogens - physiology
Female
Humans
Memory
Menopause
Middle Aged - psychology
Parity
Postmenopause - psychology
Sampling Studies
Sex Hormone-Binding Globulin - analysis
Verbal Learning
Victoria - epidemiology
Victoria
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Summary:Estrogen loss after natural menopause is hypothesized to impair episodic memory. A total of 326 women aged 52 to 63 years participating in the Melbourne Women's Midlife Health Project completed a word list memory task. Estrogen exposures were inferred from menopausal status, time from final menstrual period, use of hormone therapy, serum estradiol concentration, and other indices. Memory did not vary significantly with most exposures. The authors conclude that episodic verbal memory assessed by word list learning is not substantially affected during the menopausal transition or in the years immediately after natural menopause.
ISSN:1526-632X
DOI:10.1212/01.WNL.0000059413.75888.BE