Isoniazid-resistant cavitary tuberculosis in a physician following isoniazid prophylaxis

Single-drug prophylaxis is recommended after tuberculin skin test conversion, but not when there is active disease on chest radiograph because resistance develops frequently. Isoniazid-resistant tuberculosis developed in a physician receiving prophylaxis despite "faint left upper lobe soft tiss...

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Bibliographic Details
Published inInfection control and hospital epidemiology Vol. 23; no. 10; p. 622
Main Authors Karchmer, Tobi B, Phipps, John D, Giannetta, Eve T, Farr, Barry M
Format Journal Article
LanguageEnglish
Published United States 01.10.2002
Subjects
Adult
Antitubercular Agents - administration & dosage
Antitubercular Agents - pharmacology
Antitubercular Agents - therapeutic use
Drug Resistance, Microbial
Drug Therapy, Combination
Humans
Infectious Disease Transmission, Patient-to-Professional
Isoniazid - administration & dosage
Isoniazid - pharmacology
Isoniazid - therapeutic use
Male
Mycobacterium tuberculosis - drug effects
Radiography, Thoracic
Tuberculin Test
Tuberculosis, Pulmonary - diagnostic imaging
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - prevention & control
Tuberculosis, Pulmonary - transmission
Virginia
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Summary:Single-drug prophylaxis is recommended after tuberculin skin test conversion, but not when there is active disease on chest radiograph because resistance develops frequently. Isoniazid-resistant tuberculosis developed in a physician receiving prophylaxis despite "faint left upper lobe soft tissue density" on chest radiograph. Ignoring active disease on chest x-ray renders this strategy counterproductive and cost ineffective.
ISSN:0899-823X
DOI:10.1086/501983