Effects on Glycemic Control in Impaired Wound Healing in Spontaneously Diabetic Torii (SDT) Fatty Rats

• Published in: Medicinski arhiv Vol. 72; no. 1; pp. 4 - 8
• Main Authors: Katsuhiro, Miyajima, Hui Teoh, Soon, Yamashiro, Hideaki, Shinohara, Masami, Fatchiyah, Fatchiyah, Ohta, Takeshi, Yamada, Takahisa
• Format: Journal Article
• Language: English
• Published: Bosnia and Herzegovina Academy of Medical Sciences of Bosnia and Herzegovina 01.02.2018
• Subjects: Animals; Blood Glucose - physiology; Diabetes; Diabetes Complications - physiopathology; Diabetes Mellitus, Type 2 - complications; Disease Models, Animal; Glycemic Index - physiology; Humans; Male; Original Paper; Rats; Wound healing; Wound Healing - physiology; sodium-glucose transporter 2; blood glucose; diabetic complication; wound healing; rat
• ISSN: 0350-199X; 1986-5961
• DOI: 10.5455/medarh.2018.72.4-8

Impaired diabetic wound healing is an important issue in diabetic complications. The present study aims to evaluate the protective effect on glycemic control against impaired diabetic wound healing using a diabetic rat model. We investigated the wound healing process and effect on the impaired wound repair by glycemic control in the Spontaneously Diabetic Torii (SDT) fatty rat, which is a new animal model of obese type 2 diabetes and may be a good model for study impaired wound healing. Male SDT fatty rats at 15 weeks of age were administered orally with sodium glucose co-transporter (SGLT) 2 inhibitor for 3 weeks. Wounds were induced at 2 weeks after SGLT 2 inhibitor treatment, and the wound areas were periodically examined in morphological and histological analyses. The SDT fatty rats showed a delayed wound healing as compared with the normal rats, but a glycemic control improved the impaired wound healing. In histological analysis in the skin of SDT fatty rats showed severe infiltration of inflammatory cell, hemorrhage and many . Thought that this results skin performance to be a delay of crust formation and regeneration of epithelium; however, these findings were ameliorated in the SGLT 2 inhibitor treated group. Glycemic control is effective for treatment in diabetic wounds and the SDT fatty rat may be useful to investigate pathophysiological changes in impaired diabetic wound healing.