Dosing of Ertapenem in an Extreme Obesity: A Case Report of 250 kg Patient

Limited available data for dosing in obesity of the medicines used in this case are discussed, with the emphasis on ertapenem. The case illustrates the difficulties in dosing medicines to morbidly overweight patients. The number of such patients is increasing but data on adequate doses of medicines...

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Bibliographic Details
Published inCase Reports in Critical Care Vol. 2017; no. 2017; pp. 1 - 3
Main Authors Starkopf, Joel, Kipper, Karin, Tamme, Kadri, Lass, Jana
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2017
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Acute respiratory distress syndrome
Bacterial pneumonia
Carbapenems
Care and treatment
Case Report
Case studies
Critical care medicine
Dosage and administration
Drug therapy
Health aspects
Methods
Overweight persons
Pneumonia
Estonia
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Summary:Limited available data for dosing in obesity of the medicines used in this case are discussed, with the emphasis on ertapenem. The case illustrates the difficulties in dosing medicines to morbidly overweight patients. The number of such patients is increasing but data on adequate doses of medicines are scarce. We demonstrate that ertapenem 1,5 g i.v. once daily provided adequate drug exposure for susceptible bacteria in a 250 kg patient with normal renal function. The case suggests the usefulness of therapeutic drug monitoring of antibiotics, especially in critically ill patients.
Bibliography:Academic Editor: Mehmet Doganay
ISSN:2090-6420
2090-6439
DOI:10.1155/2017/5310768