N‐Sulfonyl‐1,2,3,4‐tetrahydroisoquinoline Derivatives: Synthesis, Antimicrobial Evaluations, and Theoretical Insights

• Published in: Chemistry & biodiversity Vol. 20; no. 11; pp. e202300905 - n/a
• Main Authors: Rinaldi Tosi, Martín E., Palermo, Valeria, Giannini, Fernando A., Fernández Baldo, Martín A., Díaz, Jorge R. A., Lima, Beatriz, Feresin, Gabriela E., Romanelli, Gustavo P., Baldoni, Héctor A.
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.11.2023
• Subjects: ADMET; antibacterial; antifungal; Antifungal activity; Antifungal agents; Catalysts; Chemical properties; Density functional theory; Food contamination; Food industry; Fungi; Fungicides; Immunotoxicity; Metabolism; Microbial contamination; Microorganisms; sulfonamide; Tetrahydroisoquinoline; tetrahydroisoquinolines; Toxicity
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.202300905

Microbial contamination remains a significant economic challenge in the food industry, emphasizing the need for innovative antimicrobial solutions. In this study, we synthesized N‐sulfonyl‐1,2,3,4‐tetrahydroisoquinolines (NSTHIQ) derivatives using an environmentally friendly Preyssler heteropolyacid catalyst, obtaining moderate to high yields (35–91 %) under mild conditions. Two derivatives (5 and 6) exhibited significant antifungal properties against various fungal species, including Aspergillus spp, Penicillium spp, and Botrytis cinerea. ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis revealed the absence of hepatic toxicity in all compounds, making derivatives 2, 3, 4, and 5 potential candidates for further development. However, derivatives 6 and 7 exhibited immunotoxicity. In support of our experimental findings, reactivity indices were computed using Density Functional Theory principles, deriving valuable insights into the chemical properties of these derivatives. This study underscores the potential of NSTHIQ compounds as potent antifungal agents, coupled with the importance of employing environmentally friendly catalysts in drug discovery.