Atypical MRI Findings in Cerebral Adrenoleukodystrophy: a Case Report

Adrenoleukodystrophy is a rare X-linked hereditary disease that results in accumulation of very-long-chain fatty acids in all body tissues, thus causing demyelination of the white matter. Magnetic resonance imaging (MRI) is a reliable radiological modality to demonstrate the extension of brain lesio...

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Published inActa clinica Croatica (Tisak) Vol. 60; no. 2; pp. 326 - 328
Main Authors Koc, Koray, Canan, Arzu, Koc, Pmar, Karaali, Kamil, Duman, Ozgiir, Senol, Utku
Format Journal Article
LanguageEnglish
Published Klinicki bolnicki centar Sestre milosrdnice 01.06.2021
Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb
Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
Subjects
Adrenoleukodystrophy
Case Reports
Case studies
Diagnosis
Magnetic resonance imaging
Pediatric research
Very-long-chain fatty acids
White matter
Turkey
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Summary:Adrenoleukodystrophy is a rare X-linked hereditary disease that results in accumulation of very-long-chain fatty acids in all body tissues, thus causing demyelination of the white matter. Magnetic resonance imaging (MRI) is a reliable radiological modality to demonstrate the extension of brain lesions and severity of the disease. In the classic form, the parieto-occipital white matter is affected. Besides, atypical MRI findings such as primary frontal lobe involvement are rarely described. We report a case of adrenoleukodystrophy presenting with rare MRI findings such as bilateral symmetric frontal lobe white matter changes suggesting anterior predominance. Key words: Adrenoleukodystrophy; Magnetic resonance imaging; Very-long-chain fatty acids; White matter
ISSN:0353-9466
1333-9451
DOI:10.20471/acc.2021.60.02.23