May mean platelet volume levels be a predictor in the diagnosis of pelvic inflammatory disease?

• Published in: Wiener Klinische Wochenschrift Vol. 126; no. 13-14; pp. 422 - 426
• Main Authors: Incebiyik, Adnan, Seker, Ahmet, Vural, Mehmet, Gul Hilali, Nese, Camuzcuoglu, Aysun, Camuzcuoglu, Hakan
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.07.2014
• Subjects: Adult; Biomarkers; Blood Sedimentation; C-Reactive Protein - metabolism; Case-Control Studies; Early Diagnosis; Endocrinology; Female; Gastroenterology; Humans; Internal Medicine; Mean Platelet Volume; Medicine; Medicine & Public Health; Original Article; Pelvic Inflammatory Disease - blood; Pelvic Inflammatory Disease - diagnosis; Platelet Count; Pneumology/Respiratory System; Predictive Value of Tests; Mean platelet volume; Platelet; C reaktives Protein; Mittleres Thrombozytenvolumen; Thrombozyten; Entzündliche Erkrankungen im Becken; Erythrozytensenkungsgeschwindigkeit; Pelvic inflammatory disease; Erythrocyte sedimentation rate; C reactive protein
• ISSN: 0043-5325; 1613-7671
• DOI: 10.1007/s00508-014-0560-2

Summary Background Our aim in this study was to investigate whether mean platelet volume (MPV) value could be used as an early marker to predict pelvic inflammatory disease (PID). Methods Overall, 44 patients with PID and 44 healthy women were included in the study. The control group consisted of 44 women who applied to the clinic for a routine gynaecological check-up, without chronic disease or a history of medication use. Owing to the fact that it would affect thrombocyte function, women who have the following conditions were excluded from the study: women who were taking anticoagulant therapy, oral contraceptives, nonsteroid anti-inflammatory medications and who had chronic diseases. The leukocyte count, platelet count, neutrophil ratio and MPV values were collected from PID and the control group. C reactive protein values of patients with PID were also noted. Results MPV values in patients with PID were lower than those in the control group. This reduction in MPV is statistically significant when the PID patient group is compared with the control group ( p  < 0.001). A negative correlation was discovered between platelet count and MPV values ( p  = 0.019, r  = − 0.425). Receiver-operating curve analysis pointed out that MPV has greater area under curve value than neutrophil rate, leukocyte and platelet count (0.73, 0.64, 0.72 and 0.49 respectively). Conclusion Since the MPV value was significantly decreased in patients with PID, it may serve as an additional and even more valuable marker than leukocyte count in the diagnosis of PID.