Hepatic focal nodular hyperplasia after liver transplantation: case report and review of literature

Patients with decompensated cirrhosis complicated by hepatocellular carcinoma (HCC) or those who have undergone liver transplantation following liver failure after HCC treatment should continue to receive post-transplant surveillance. Any new liver tumor must be carefully evaluated to determine whet...

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Published inClinical journal of gastroenterology
Main Authors Nakamura, Kenichi, Ozono, Yoshinori, Hasuike, Satoru, Hatada, Hiroshi, Uchiyama, Naomi, Komaki, Yuri, Iwakiri, Hisayoshi, Nagata, Kenji, Umekita, Yoshiko, Aishima, Shinichi, Kawakami, Hiroshi
Format Journal Article
LanguageEnglish
Published Japan 18.07.2025
Subjects
Hepatocellular carcinoma
Focal nodular
Hyperplasia
Liver transplantation
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ISSN1865-7257
1865-7265
1865-7265
DOI10.1007/s12328-025-02180-5

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Summary:Patients with decompensated cirrhosis complicated by hepatocellular carcinoma (HCC) or those who have undergone liver transplantation following liver failure after HCC treatment should continue to receive post-transplant surveillance. Any new liver tumor must be carefully evaluated to determine whether it is a recurrence of HCC. Focal nodular hyperplasia (FNH), the second most common benign hepatic tumor, is believed to result from the hyperplastic response of hepatocytes to pre-existing vascular malformation. Here, we report a case of hepatic FNH two years after living-donor liver transplantation in a patient who experienced liver failure following treatment for HCC. Given the rarity of hepatic FNH after liver transplantation, we present this case along with a review of the literature.
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ISSN:1865-7257
1865-7265
1865-7265
DOI:10.1007/s12328-025-02180-5